Yes but if I'm the one writing in memory database/analytics stuff I might want to use a Python/C combination to do that. Right now that's not an option because of the GIL issue.

But don't you want your in-memory database to be non-locking, i.e. serving many clients simultaneously and fast?

The point was your in-memory database is an external, non-python program, and you run lots of python clients.

The way most web applications are structured, for instance.