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https://www.nature.com/articles/s41586-025-08683-y

This seems to be the paper, but its behind a paywall.

Anyone with access can tell me if they publish the 12mer amino acid sequence? Is there more to it (post translational modifications)

Or is it just the peptide?



Note, I have access but this is not my field. I just asked ChatGPT your question after have it read the paper. This is what the response was:

Yes, the paper provides the 12-mer amino acid sequence of BRP: THRILRRLFNLC .

Regarding post-translational modifications, the BRP peptide was synthesized with a C-terminal amidation, which was critical for its bioactivity. The non-amidated version of BRP was inactive in vitro . Additionally, the paper mentions that the C-terminal cysteine (C12) was synthesized as a free thiol .

So, BRP is not just a simple peptide—it has a key post-translational modification (C-terminal amidation) that influences its function.


Very nice, thank you. This indeed answers my question.




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