They definitely didn't care about that. No language that uses ` , the most painful common character to write on most non-US keyboards put any consideration into that.
Outside of the US and a few other English-speaking countries? Not really. In Europe, US keyboards are nowhere to be found (the UK uses a different layout).
It's part of why it's always painful to buy a keyboard west of Oder for me, because Poland use ANSI layout as base, not ISO, at least as an option. After over a decade, even Microsoft finally learnt to default to "Polish (Programmers)" rather than "Polish (214)" keyboard when installing the OS (it was a common pitfall across whole Windows 9x).
Other languages in former Warsaw Pact tend to have "Programmers" layout available as well, because the national standard layouts tended to be designed for typewriters not programming and lack all kinds of characters people need - unless you go trigram route in C/C++.
For what its worth, Common Lisp at least does let you remap ` and such :)
I'm not talking about the physical ISO vs ANSI layouts. I mean the layout in software. It's not even close. Basically noone outside the US and Canada uses it. We're on HN, so obviously someone here will, but outside of this niche? Noone